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Polycythemia vera (pol-e-sy-THEE-me-uh VEER-uh) is a type of blood cancer. PV is caused by a genetic mutation and typically develops slowly, over several years. They also cause complications, such as blood clots, which can lead to a heart attack or stroke.Polycythemia vera isn't common. People with polycythemia have an increase in hematocrit, hemoglobin, or red blood cell count above the normal limits. Symptoms may include:These symptoms may look like other blood disorders or health problems. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Your body needs iron to produce the … The HFE gene has two common mutations, C282Y and H63D. This can lead to strokes or tissue and organ damage.Polycythemia vera is caused by a genetic change (mutation) that develops during your lifetime. You should also be physically active in order to increase your heart rate and improve your blood flow.You should also avoid situations in which you could be hurt, and check your feet for any sores.Tips to help you get the most from a visit to your healthcare provider: Open the Johns Hopkins Medicine menu with the enter key and close it with the escape key; use the tab keys to navigate links.Open the Johns Hopkins search window with the enter key and close it with the escape key; When you suffer a wound or cut, your body forms a blood clot to stop the bleeding - …
If you have an immediate family member who has hemochromatosis, ask your doctor about genetic tests that can determine if you have inherited the gene that increases your risk of hemochromatosis.A normal liver (left) shows no signs of scarring. If you have problems viewing PDF files, download the latest version of Adobe Reader. Polycythaemia, also known as erythrocytosis, means having a high concentration of red blood cells in your blood. Polycythemia is a condition that results in an increased level of circulating red blood cells in the bloodstream. Always see your healthcare provider for a diagnosis.Your healthcare provider will take your medical history and give you a physical exam. A lack of the mineral iron in your blood commonly causes this disorder. Following post-doctoral training at UCSF, he directed courses in neuroscience and histology for first year medical students and has also taught in anatomy, physiology and biostatistics. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Many of the symptoms of polycythaemia are caused by this sluggish flow of blood. Signs and symptoms of hereditary hemochromatosis usually appear in midlife.Treatment includes regularly removing blood from your body. Because much of the body's iron is contained in red blood cells, this treatment lowers iron levels.Some people with hereditary hemochromatosis never have symptoms. These disorders usually cause blood clots in veins including deep vein thrombosis (DVT) of the arms or legs, pulmonary embolism, and blood clots in the brain, intestines and kidneys. Many people are not diagnosed with these conditions until later in life. They will also check if there are other conditions that could cause your higher red blood cell count.Your healthcare provider will figure out the best treatment based on:Polycythemia vera can be fatal if not diagnosed and treated. A single copy of these materials may be reprinted for noncommercial personal use only. Each person’s symptoms may vary. Too much iron can lead to life-threatening conditions, such as liver disease, heart problems and diabetes.The genes that cause hemochromatosis are inherited, but only a minority of people who have the genes ever develop serious problems. Some people might develop vague symptoms such as headache, dizziness, fatigue and blurred vision.More-specific symptoms of polycythemia vera include:Make an appointment with your doctor if you have signs or symptoms of polycythemia vera.Polycythemia vera occurs when a mutation in a gene causes a problem with blood cell production.
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