2001
https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEwMzc2NS10cmVhdG1lbnQ= 1-193. Pretibial myxedema is a rare manifestation of Graves disease and is generally associated with ophthalmopathy. It is not related to thyroid function. Schwartz KM, Fatourechi V, Ahmed DD, Pond GR. Pretibial myxedema (myxoedema (UK), also known as Graves' dermopathy, thyroid dermopathy, Jadassohn-Dösseker disease or Myxoedema tuberosum) is an infiltrative dermopathy, resulting as a rare complication of Graves' disease, with an incidence rate of about 1-5%. Heufelder AE, Bahn RS, Scriba PC. An endpoint to treatment is based on what the patient hopes to have accomplished, be it cosmetic and/or functional improvement. Pretibial myxedema may undergo partial or complete remission and is primarily a cosmetic concern. Pineda AM, Tianco EA, Tan JB, Casintahan FA, Beloso MB. Pre-tibial myxedema: treatment with intralesional corticosteroid.
Its pathogenesis is still under investigation. This should be used in conjunction with all treatment modalities, if possible. 2010
Successful therapeutic approach in a patient with elephantiasic pretibial myxedema. His thyroid function tests were suggestive of primary idiopathic … Graves' dermopathy results from a buildup of certain carbohydrates in the skin — the cause of which isn't known.
As scars may worsen TD, any surgical procedure must be approached with caution. Plaques may be observed individually or on a background of diffuse involvement. Journal Article
Response to topical halcinonide following fractional carbon dioxide laser pretreatment in a pretibial myxedema patient.
Missner SC, Ramsay EW, Houck HE, Kauffman CL. Glycosaminoglycans, also called mucopolysaccharides, are complex carbohydrates that are important for tissue hydration and lubrication. Engin, B, Gumusel, M, Ozdemir, M, Cakir, M. “Successful combined pentoxifylline and intralesional triamcinolone acetonide treatment of severe pretibial myxedema”. 2001
Potent (betamethasone diproprionate 0.05%, or equivalent) and ultrapotent (clobetasol 0.05% or equivalent) topical steroids with or without occlusion are the cornerstones of treating pretibial myxedema.
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If you have any concerns with your skin or its treatment, see a dermatologist for advice.
Pretibial myxedema (also called localized myxedema, thyroid dermopathy, or infiltrative dermopathy) is an infrequent manifestation of Graves' disease.
This interesting case report reminds us that even in such rare presentations, patients may be euthyroid at the time of presentation. Fractional laser ablation has been reported as beneficial.A dermatologist should be consulted for an evaluation of lesions in suspected PTM and an endocrinologist for an evaluation of possible underlying thyroid disease.Doshi DN, Blyumin ML, Kimball AB. Inquire about any associated autoimmune diseases as patients with Graves disease (and Hashimoto’s thyroiditis) have an increased risk other immunologically-mediated diseases such as diabetes mellitus, immunobullous diseases, and collagen vascular diseases. Fatourechi V, Bartley GB, Eghbali-Fatourechi GZ, Powell CC, Ahmed DD, Garrity JA. This website also contains material copyrighted by 3rd parties.
